Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential func...

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Main Authors: Bresnick, Emery H., Katsumura, Koichi R., Lee, Hsiang-Ying, Johnson, Kirby D., Perkins, Archibald S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
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Survey and Summary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401466/
https://ncbi.nlm.nih.gov/pubmed/22492510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks281
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