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siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs
While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a pr...
Tallennettuna:
| Päätekijät: | , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401429/ https://ncbi.nlm.nih.gov/pubmed/22422842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks239 |
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