Absence of the inhibitory G-protein, Gα(i2), predisposes to ventricular cardiac arrhythmia

BACKGROUND: We have explored the role that inhibitory heterotrimeric G-proteins have in ventricular arrhythmia. METHODS AND RESULTS: We studied mice with global genetic deletion of Gα(i2) (Gα(i2) (−/−)) and find that they have a prolonged QT interval on the surface ECG when awake and studied with te...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zuberi, Zia, Nobles, Muriel, Sebastian, Sonia, Dyson, Alex, Lim, Shiang Y, Breckenridge, Ross, Birnbaumer, Lutz, Tinker, Andrew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401367/
https://ncbi.nlm.nih.gov/pubmed/20495013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.109.894329
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