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Absence of the inhibitory G-protein, Gα(i2), predisposes to ventricular cardiac arrhythmia
BACKGROUND: We have explored the role that inhibitory heterotrimeric G-proteins have in ventricular arrhythmia. METHODS AND RESULTS: We studied mice with global genetic deletion of Gα(i2) (Gα(i2) (−/−)) and find that they have a prolonged QT interval on the surface ECG when awake and studied with te...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401367/ https://ncbi.nlm.nih.gov/pubmed/20495013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.109.894329 |
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