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Antigen-driven Induction of Polyreactive IgM during Intracellular Bacterial Infection

Polyreactivity is well known as a property of natural IgM produced by B-1 cells. We demonstrate that polyreactive IgM is also generated during infection of mice with Ehrlichia muris, a tick-borne intracellular bacterial pathogen. The polyreactive IgM bound self and foreign antigens, including single...

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Main Authors: Jones, Derek D., DeIulio, Gregory A., Winslow, Gary M.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401281/
https://ncbi.nlm.nih.gov/pubmed/22730531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200878
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