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Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization

Cullin E3 ligases are the largest family of ubiquitin ligases with diverse cellular functions. One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit ubiquitin ligase complex. Cullin binds the RING domain protein Rbx1/Rbx2 via its C-terminus and a cullin-speci...

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Autors principals: Choo, Yin Yin, Hagen, Thilo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401178/
https://ncbi.nlm.nih.gov/pubmed/22911784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041350
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