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Molecular and Thermodynamic Insights into the Conformational Transitions of Hsp90
Hsp90, the most abundant cellular protein, has been implicated in numerous physiological and pathological processes. It controls protein folding and prevents aggregation, but it also plays a role in cancer and neurological disorders, making it an attractive drug target. Experimental efforts have dem...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400771/ https://ncbi.nlm.nih.gov/pubmed/22853906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.06.018 |
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