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Molecular and Thermodynamic Insights into the Conformational Transitions of Hsp90

Hsp90, the most abundant cellular protein, has been implicated in numerous physiological and pathological processes. It controls protein folding and prevents aggregation, but it also plays a role in cancer and neurological disorders, making it an attractive drug target. Experimental efforts have dem...

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Détails bibliographiques
Auteurs principaux: Simunovic, Mijo, Voth, Gregory A.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400771/
https://ncbi.nlm.nih.gov/pubmed/22853906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.06.018
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