Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice

BACKGROUND: Cardiovascular disorders associated with endothelial dysfunction, such as atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature can compete with eNOS for L-arginine and has been implicated in atherosclerosis. The aim of this study was to evaluate...

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Detalhes bibliográficos
Main Authors: Vaisman, Boris L., Andrews, Karen L., Khong, Sacha M. L., Wood, Katherine C., Moore, Xiao L., Fu, Yi, Kepka-Lenhart, Diane M., Morris, Sidney M., Remaley, Alan T., Chin-Dusting, Jaye P. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400622/
https://ncbi.nlm.nih.gov/pubmed/22829869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039487
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