Arginase II inhibition prevents nitrate tolerance

BACKGROUND AND PURPOSE: Nitrate tolerance, the loss of vascular responsiveness with continued use of nitrates, remains incompletely understood and is a limitation of these therapeutic agents. Vascular superoxide, generated by uncoupled endothelial NOS (eNOS), may play a role. As arginase competes wi...

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Bibliographische Detailangaben
Hauptverfasser: Khong, SML, Andrews, KL, Huynh, NN, Venardos, K, Aprico, A, Michell, DL, Zarei, M, Moe, KT, Dusting, GJ, Kaye, DM, Chin-Dusting, JPF
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2012
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402767/
https://ncbi.nlm.nih.gov/pubmed/22288373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01876.x
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