Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells

Vaccines may help reduce the growing incidence of fungal infections in immune-suppressed patients. We have found that, even in the absence of CD4(+) T-cell help, vaccine-induced CD8(+) T cells persist and confer resistance against Blastomyces dermatitidis and Histoplasma capsulatum. Type 1 cytokines...

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Hauptverfasser: Nanjappa, Som Gowda, Heninger, Erika, Wüthrich, Marcel, Gasper, David Joseph, Klein, Bruce S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400565/
https://ncbi.nlm.nih.gov/pubmed/22829762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002771
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