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Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

Fungal infections have skyrocketed in immune-compromised patients lacking CD4+ T cells, underscoring the need for vaccine prevention. An understanding of the elements that promote vaccine immunity in this setting is essential. We previously demonstrated that vaccine-induced IL-17A+ CD8+ T cells (Tc1...

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Detalhes bibliográficos
Main Authors: Som Gowda Nanjappa, Nydiaris Hernández-Santos, Kevin Galles, Marcel Wüthrich, M Suresh, Bruce S Klein
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-09-01
Colecção:PLoS Pathogens
Acesso em linha:https://doi.org/10.1371/journal.ppat.1005161
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