Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1

Fulvestrant (Faslodex™) is a pure antiestrogen that is approved to treat hormone receptor-positive metastatic breast cancer in postmenopausal women. Previous studies have demonstrated that fulvestrant metabolism in humans involves cytochromes P450 and UDP-glucuronosyltransferases (UGTs). To date, fu...

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Главные авторы: Edavana, Vineetha Koroth, Yu, Xinfeng, Dhakal, Ishwori B, Williams, Suzanne, Ning, Baitang, Cook, Ian T, Caldwell, David, Falany, Charles N, Kadlubar, Susan
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2011
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400326/
https://ncbi.nlm.nih.gov/pubmed/22822301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S25418
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