p47(phox)-deficient immune microenvironment signals dysregulate naive T cell apoptosis

The phagocyte NADPH oxidase is a multi-component enzyme complex mediating microbial killing. We find that NADPH oxidase p47(phox) deficient (p47(phox-/-)) chronic granulomatous disease (CGD) mice develop lymph node hyperplasia even without obvious infection, where increased number of T and B lymphoc...

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Detalhes bibliográficos
Main Authors: Donaldson, Mitzi, Antignani, Antonella, Milner, Joshua, Zhu, Nannan, Wood, Adam, Cardwell-Miller, Lanise, Changpriroa, Cattlena May, Jackson, Sharon H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400273/
https://ncbi.nlm.nih.gov/pubmed/18806761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.129
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