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Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor
Telaprevir, a novel hepatitis C virus (HCV) NS3-4A serine protease inhibitor, has demonstrated substantial antiviral activity in patients infected with HCV. However, drug-resistant HCV variants were detected in vivo at relatively high frequency a few days after drug administration. Here we use a two...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400267/ https://ncbi.nlm.nih.gov/pubmed/22639338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11538-012-9736-y |
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