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Impairment of Osteoblast Differentiation Due to Proliferation-independent Telomere Dysfunction in Mouse Models of Accelerated Aging

We undertook genetic and non-genetic approaches to investigate the relationship between telomere maintenance and osteoblast differentiation, as well as to uncover a possible link between a known mediator of cellular aging and senile bone loss. Using mouse models of disrupted telomere maintenance mol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Haitao, Chen, Qijun, Lee, Seoung-Hoon, Choi, Yongwon, Johnson, F. Brad, Pignolo, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400025/
https://ncbi.nlm.nih.gov/pubmed/22621437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00838.x
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