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Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis
Osteoporosis and the associated risk of fracture are major clinical challenges in the elderly. Telomeres shorten with age in most human tissues, including bone, and because telomere shortening is a cause of cellular replicative senescence or apoptosis in cultured cells, including mesenchymal stem ce...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394673/ https://ncbi.nlm.nih.gov/pubmed/18028256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2007.00350.x |
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