Opposing Regulation of Cytochrome P450 Expression by CAR and PXR in Hypothyroid Mice

Clinical hypothyroidism affects various metabolic processes including drug metabolism. CYP2B and CYP3A are important cytochrome P450 drug metabolizing enzymes that are regulated by the xenobiotic receptors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2). We evaluat...

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Main Authors: Park, Young Joo, Lee, Eun Kyung, Lee, Yoon Kwang, Park, Do Joon, Jang, Hak Chul, Moore, David D.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399920/
https://ncbi.nlm.nih.gov/pubmed/22503787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.03.017
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