BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner

BACKGROUND: K-RAS mutation poses a particularly difficult problem for cancer therapy. Activating mutations in K-RAS are common in cancers of the lung, pancreas, and colon and are associated with poor response to therapy. As such, targeted therapies that abrogate K-RAS-induced oncogenicity would be o...

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Hlavní autoři: Lau, Ken S., Zhang, Tinghu, Kendall, Krystle R., Lauffenburger, Douglas, Gray, Nathanael S., Haigis, Kevin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399817/
https://ncbi.nlm.nih.gov/pubmed/22815993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041343
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