Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells

Breast cancer cells generally develop resistance to TNF-Related Apoptosis-Inducing Ligand (TRAIL) and, therefore, assistance from sensitizers is required. In our study, we have demonstrated that Spleen tyrosine kinase (Syk) inhibitor Bay 61–3606 was identified as a TRAIL sensitizer. Amplification of...

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Udgivet i:PLoS One
Main Authors: Kim, So-Young, Park, Sang Eun, Shim, Sang-Mi, Park, Sojung, Kim, Kyung Kon, Jeong, Seong-Yun, Choi, Eun Kyung, Hwang, Jung Jin, Jin, Dong-Hoon, Chung, Christopher Doosoon, Kim, Inki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697837/
https://ncbi.nlm.nih.gov/pubmed/26720004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146073
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