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Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively-impaired phencyclidine-treated monkeys

Schizophrenic patients, long-term abusers of phencyclidine (PCP), and monkeys treated with PCP all exhibit enduring cognitive deficits. Evidence indicates that loss of prefrontal cortex spine synapses results in cognitive dysfunction, suggesting the presence of synaptic pathology in the monkey PCP m...

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Bibliografiske detaljer
Main Authors: Elsworth, John D., Hajszan, Tibor, Leranth, Csaba, Roth, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399728/
https://ncbi.nlm.nih.gov/pubmed/21733230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145711000939
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