Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma

BACKGROUND AND AIMS: The combination of polyamine and prostaglandin E2 (PGE2) synthesis inhibitors reduced the risk of colorectal adenoma (CRA) by 70% in patients that received polypectomies. We studied the effects of the combination of difluoromethylornithine (DFMO) and sulindac on biomarkers and i...

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Главные авторы: Thompson, Patricia A., Wertheim, Betsy C., Zell, Jason A., Chen, Wen-Pin, McLaren, Christine E., LaFleur, Bonnie J., Meyskens, Frank L., Gerner, Eugene W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399666/
https://ncbi.nlm.nih.gov/pubmed/20538001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.06.005
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