Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas

BACKGROUND: The polyamine-inhibitory regimen difluoromethylornithine (DFMO)+sulindac has marked efficacy in preventing metachronous colorectal adenomas. Polyamines are synthesised endogenously and obtained from dietary sources. Here we investigate dietary polyamine intake and outcomes in the DFMO+su...

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Detalhes bibliográficos
Main Authors: Raj, K P, Zell, J A, Rock, C L, McLaren, C E, Zoumas-Morse, C, Gerner, E W, Meyskens, F L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593561/
https://ncbi.nlm.nih.gov/pubmed/23340449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.15
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