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A new perspective on Hsp104-mediated propagation and curing of the yeast prion [PSI(+)]

Most prions in yeast form amyloid fibrils that must be severed by the protein disaggregase Hsp104 to be propagated and transmitted efficiently to newly formed buds. Only one yeast prion, [PSI(+)], is cured by Hsp104 overexpression. We investigated the interaction between Hsp104 and Sup35, the priong...

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Autori principali: Helsen, Christopher W., Glover, John R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399534/
https://ncbi.nlm.nih.gov/pubmed/22561166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.19913
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