The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells

A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471∶518-22, 2011). We previously reported that leflunomide strongly activates the transcriptional activity of the Aryl Hydrocarbon Receptor (AhR). We there...

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Autors principals: O’Donnell, Edmond F., Kopparapu, Prasad Rao, Koch, Daniel C., Jang, Hyo Sang, Phillips, Jessica Lynne, Tanguay, Robert L., Kerkvliet, Nancy I., Kolluri, Siva Kumar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398955/
https://ncbi.nlm.nih.gov/pubmed/22815870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040926
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