The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2

SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial se...

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Detalhes bibliográficos
Main Authors: Condé, Claude, Rambout, Xavier, Lebrun, Marielle, Lecat, Aurore, Di Valentin, Emmanuel, Dequiedt, Franck, Piette, Jacques, Gloire, Geoffrey, Legrand, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398883/
https://ncbi.nlm.nih.gov/pubmed/22815893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041005
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