AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit

Histone hypoacetylation occurs in many cancers and inhibition of histone deacetylation is a promising approach to modulate these epigenetic changes. Our laboratory previously demonstrated that the histone deacetylase inhibitors (HDACis) vorinostat and AR-42 reduced the viability of a canine malignan...

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Autori principali: Lin, Tzu-Yin, Fenger, Joelle, Murahari, Sridhar, Bear, Misty D., Kulp, Samuel K., Wang, Dasheng, Chen, Ching-Shih, Kisseberth, William C., London, Cheryl A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398750/
https://ncbi.nlm.nih.gov/pubmed/20233974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231985
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