KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Activating mutations in codon D816 of the tyrosine kinase receptor, KIT, are found in the majority of patients with systemic mastocytosis. We found that the transcription factor, microphthalmia-associated transcription factor (MITF), is highly expressed in bone marrow biopsies from 9 of 10 patients...

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Autors principals: Lee, Youl-Nam, Brandal, Stephanie, Noel, Pierre, Wentzel, Erik, Mendell, Joshua T., McDevitt, Michael A., Kapur, Reuben, Carter, Melody, Metcalfe, Dean D., Takemoto, Clifford M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072881/
https://ncbi.nlm.nih.gov/pubmed/21273305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-293548
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