KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Activating mutations in codon D816 of the tyrosine kinase receptor, KIT, are found in the majority of patients with systemic mastocytosis. We found that the transcription factor, microphthalmia-associated transcription factor (MITF), is highly expressed in bone marrow biopsies from 9 of 10 patients...

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書誌詳細
主要な著者: Lee, Youl-Nam, Brandal, Stephanie, Noel, Pierre, Wentzel, Erik, Mendell, Joshua T., McDevitt, Michael A., Kapur, Reuben, Carter, Melody, Metcalfe, Dean D., Takemoto, Clifford M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2011
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072881/
https://ncbi.nlm.nih.gov/pubmed/21273305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-293548
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