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Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue

In this Letter, we describe the first total synthesis of cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata, with anticholinergic activity as well as an unnatural analogue. The streamlined synthesis proceeds in 9 steps, 7 steps longest linear sequence, in 25.2% overall yield, and fea...

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書誌詳細
主要な著者: Hahn, Kristopher N., Fadeyi, Olugbeminiyi O., Cho, Hyekyung P., Lindsley, Craig W.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398747/
https://ncbi.nlm.nih.gov/pubmed/22822275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.05.009
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