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Rat CYP2D2, not 2D1, is functionally conserved with human CYP2D6 in endogenous morphine formation
The assumption that CYP2D1 is the corresponding rat cytochrome to human CYP2D6 has been revisited using recombinant proteins in direct enzyme assays. CYP2D1 and 2D2 were incubated with known CYP2D6 substrates, the three morphine precursors thebaine, codeine and (R)-reticuline. Mass spectrometric ana...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3398485/ https://ncbi.nlm.nih.gov/pubmed/22641033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.05.021 |
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