Potential genotype-specific single nucleotide polymorphism interaction of common variation in p53 and its negative regulator mdm2 in cholangiocarcinoma susceptibility

Aberrant cell cycle control and apoptosis deregulation are involved in biliary carcinogenesis. The tumor suppressor gene p53 and its key negative regulator murine double minute 2 (mdm2) cooperate in modulating these basic cell functions and germline p53 alteration promotes cholangiocarcinoma (CCA) f...

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Bibliografiske detaljer
Main Authors: ZIMMER, VINCENT, HÖBLINGER, AKSANA, MIHALACHE, FLORENTINA, ASSMANN, GUNTER, ACALOVSCHI, MONICA, LAMMERT, FRANK
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398355/
https://ncbi.nlm.nih.gov/pubmed/22807971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.680
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