A ubiquitin-binding protein FAAP20 links RNF8-mediated ubiquitination to the Fanconi anemia DNA Repair network

The Fanconi anemia (FA) protein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism remains unclear. Here we show that the network is regulated by a ubiquitin signaling cascade initiated by RNF8 and its partner, UBC13; and mediated by FAAP20, a component o...

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Autors principals: Yan, Zhijiang, Guo, Rong, Paramasivam, Manikandan, Shen, Weiping, Ling, Chen, Fox, David, Wang, Yucai, Oostra, Anneke B., Kuehl, Julia, Lee, Duck-Yeon, Takata, Minoru, Hoatlin, Maureen E., Schindler, Detlev, Joenje, Hans, de Winter, Johan P., Li, Lei, Seidman, Michael M., Wang, Weidong
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398238/
https://ncbi.nlm.nih.gov/pubmed/22705371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.026
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