Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer

BACKGROUND: Gene-directed enzyme prodrug therapy (GDEPT) is a two-step treatment protocol for solid tumors that involves the transfer of a gene encoding a prodrug-activating enzyme followed by administration of the inactive prodrug that is subsequently activated by the enzyme to its tumor toxic form...

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Detalhes bibliográficos
Main Authors: Hlavaty, Juraj, Petznek, Helga, Holzmüller, Harry, Url, Angelika, Jandl, Gerrit, Berger, André, Salmons, Brian, Günzburg, Walter H., Renner, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398047/
https://ncbi.nlm.nih.gov/pubmed/22815775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040611
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