Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases

Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is associated with many human diseases including...

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Huvudupphovsmän: Ortiz-Sanchez, Juan Manuel, Nichols, Sara E., Sayyah, Jacqueline, Brown, Joan Heller, McCammon, J. Andrew, Grant, Barry J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397943/
https://ncbi.nlm.nih.gov/pubmed/22815826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040809
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