Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of liver cancer cell lines requires death receptor-5 (DR5)-dependent permeabilization of lysosomal membranes. Ligated DR5 triggers recruitment of the proapoptotic proteins Bim and Bax to lysosomes, releasing cathepsin...

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Bibliographische Detailangaben
Hauptverfasser: Werneburg, Nathan W., Bronk, Steve F., Guicciardi, Maria Eugenia, Thomas, Laurel, Dikeakos, Jimmy D., Thomas, Gary, Gores, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397868/
https://ncbi.nlm.nih.gov/pubmed/22645134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342238
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