Protein Kinase Cα and Src Kinase Support Human Prostate-distributed Dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 Activity

Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5α-dihydrotestosterone (DHT) and 3α-androstane-5α,17β-diol metabolite, we sought to determine whether 2B15 requires regulated phosphorylation similar to UGTs already analyzed. Reversible down-regulation of 2B15-tra...

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Bibliographische Detailangaben
Hauptverfasser: Chakraborty, Sunit K., Basu, Nikhil K., Jana, Sirsendu, Basu, Mousumi, Raychoudhuri, Amit, Owens, Ida S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397865/
https://ncbi.nlm.nih.gov/pubmed/22532564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335067
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