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The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

Metformin, an anti-diabetic drug, exerts cardioprotection against ischemia-reperfusion (IR) through the activation of AMPK. However, the molecular mechanisms underlying these beneficial effects remain elusive. In this study, we examined the role of PPARα in mediating cardioprotective effects of metf...

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Main Authors: Barreto-Torres, Giselle, Parodi-Rullán, Rebecca, Javadov, Sabzali
Format: Artigo
Jezik:Inglês
Izdano: Molecular Diversity Preservation International (MDPI) 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397554/
https://ncbi.nlm.nih.gov/pubmed/22837722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13067694
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