High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

Aim: Sirtuins are NAD(+)-dependent deacetylases that regulate cell metabolism through protein acetylation/deacetylation, and SIRT3 is the major deacetylase among mitochondrial isoforms. Here, we elucidated the possible role of acetylation of cyclophilin D, a key regulator of the mitochondrial permea...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Parodi-Rullán, Rebecca M., Chapa-Dubocq, Xavier, Rullán, Pedro J., Jang, Sehwan, Javadov, Sabzali
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432544/
https://ncbi.nlm.nih.gov/pubmed/28559847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00275
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