Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog

We have recently designed and synthesized a novel iminoquinone anticancer agent, 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one (FBA-TPQ) and initiated its preclinical development. Herein we investigated its efficacy, safety, and pharmacokinetics in in vitro and in viv...

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Hauptverfasser: Zhang, Xiangrong, Xu, Hongxia, Zhang, Xu, Voruganti, Sukesh, Murugesan, Srinivasan, Nadkarni, Dwayaja H., Velu, Sadanandan E., Wang, Ming-Hai, Wang, Wei, Zhang, Ruiwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397457/
https://ncbi.nlm.nih.gov/pubmed/22822362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md10051138
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