Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

Seven-transmembrane receptors (7TMRs) are involved in nearly all aspects of chemical communications and represent major drug targets. 7TMRs transmit their signals not only via heterotrimeric G proteins but also through β-arrestins, whose recruitment to the activated receptor is regulated by G protei...

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Main Authors: Heitzler, Domitille, Durand, Guillaume, Gallay, Nathalie, Rizk, Aurélien, Ahn, Seungkirl, Kim, Jihee, Violin, Jonathan D, Dupuy, Laurence, Gauthier, Christophe, Piketty, Vincent, Crépieux, Pascale, Poupon, Anne, Clément, Frédérique, Fages, François, Lefkowitz, Robert J, Reiter, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397412/
https://ncbi.nlm.nih.gov/pubmed/22735336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.22
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