Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: application to an oral bioavailability study of genistein in mice

The purpose of this research was to develop a sensitive and reproducible UPLC-MS/MS method to simultaneously quantify genistein, genistein-7-O-glucuronide (G-7-G), genistein-4’-O-glucuronide (G-4’-G), genistein-4’-O-sulfate (G-4’-S) and genistein-7-Osulfate (G-7-S) in mouse blood samples. After the...

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Bibliografiske detaljer
Main Authors: Yang, Zhen, Zhu, Wei, Gao, Song, Xu, Haiyan, Wu, Baojian, Kulkarni, Kaustubh, Singh, Rashim, Tang, Lan, Hu, Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397253/
https://ncbi.nlm.nih.gov/pubmed/20378296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2010.03.011
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