Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM controls DSB repair. Optimal repair requires chromatin relaxation at damaged sites. Chromatin reorga...

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Hauptverfasser: Moyal, Lilach, Lerenthal, Yaniv, Gana-Weisz, Mali, Mass, Gilad, So, Sairei, Wang, Shih-Ya, Eppink, Berina, Chung, Young Min, Shalev, Gil, Shema, Efrat, Shkedy, Dganit, Smorodinsky, Nechama I., van Vliet, Nicole, Kuster, Bernhard, Mann, Matthias, Ciechanover, Aaron, Dahm-Daphi, Jochen, Kanaar, Roland, Hu, Mickey C.-T., Chen, David J., Oren, Moshe, Shiloh, Yosef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397146/
https://ncbi.nlm.nih.gov/pubmed/21362549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.015
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