The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

Histone monoubiquitylation is implicated in critical regulatory processes. We explored the roles of histone H2B ubiquitylation in human cells by reducing the expression of hBRE1/RNF20, the major H2B-specific E3 ubiquitin ligase. While H2B ubiquitylation is broadly associated with transcribed genes,...

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Библиографические подробности
Главные авторы: Shema, Efrat, Tirosh, Itay, Aylon, Yael, Huang, Jing, Ye, Chaoyang, Moskovits, Neta, Raver-Shapira, Nina, Minsky, Neri, Pirngruber, Judith, Tarcic, Gabi, Hublarova, Pavla, Moyal, Lilach, Gana-Weisz, Mali, Shiloh, Yosef, Yarden, Yossef, Johnsen, Steven A., Vojtesek, Borivoj, Berger, Shelley L., Oren, Moshe
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2008
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559905/
https://ncbi.nlm.nih.gov/pubmed/18832071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1703008
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