The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

Histone monoubiquitylation is implicated in critical regulatory processes. We explored the roles of histone H2B ubiquitylation in human cells by reducing the expression of hBRE1/RNF20, the major H2B-specific E3 ubiquitin ligase. While H2B ubiquitylation is broadly associated with transcribed genes,...

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Dettagli Bibliografici
Autori principali: Shema, Efrat, Tirosh, Itay, Aylon, Yael, Huang, Jing, Ye, Chaoyang, Moskovits, Neta, Raver-Shapira, Nina, Minsky, Neri, Pirngruber, Judith, Tarcic, Gabi, Hublarova, Pavla, Moyal, Lilach, Gana-Weisz, Mali, Shiloh, Yosef, Yarden, Yossef, Johnsen, Steven A., Vojtesek, Borivoj, Berger, Shelley L., Oren, Moshe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559905/
https://ncbi.nlm.nih.gov/pubmed/18832071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1703008
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