PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes

BACKGROUND: PI3Kδ is a lipid kinase of the phosphoinositide 3-kinase class 1A family and involved in early signaling events of leukocytes regulating proliferation, differentiation and survival. Currently, several inhibitors of PI3Kδ are under investigation for the treatment of hematopoietic malignan...

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Autori principali: Putz, Eva Maria, Prchal-Murphy, Michaela, Simma, Olivia Annabella, Forster, Florian, Koenig, Xaver, Stockinger, Hannes, Piekorz, Roland P., Freissmuth, Michael, Müller, Mathias, Sexl, Veronika, Zebedin-Brandl, Eva
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396622/
https://ncbi.nlm.nih.gov/pubmed/22808277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040852
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