The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms the cells into a highly aggressive phenotype and controls both lipooxygenase-5 (LOX-5)...

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Bibliographic Details
Main Authors: Orlando, Ulises D., Garona, Juan, Ripoll, Giselle V., Maloberti, Paula M., Solano, Ángela R., Avagnina, Alejandra, Gomez, Daniel E., Alonso, Daniel F., Podestá, Ernesto J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396606/
https://ncbi.nlm.nih.gov/pubmed/22808264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040794
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