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The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.
The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms the cells into a highly aggressive phenotype and controls both lipooxygenase-5 (LOX-5)...
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Autori principali: | , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Public Library of Science (PLoS)
2012-01-01
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Serie: | PLoS ONE |
Accesso online: | http://europepmc.org/articles/PMC3396606?pdf=render |
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