Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma. ACSL4 mainly esterifies arachidonic acid (AA) into arachidonoyl-CoA, reducing free AA intracellular levels, which is in contradiction with the need for AA metabolites in tumorigenesis. Therefore, the...

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Detalhes bibliográficos
Main Authors: Maloberti, Paula M., Duarte, Alejandra B., Orlando, Ulises D., Pasqualini, María E., Solano, Ángela R., López-Otín, Carlos, Podestá, Ernesto J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978721/
https://ncbi.nlm.nih.gov/pubmed/21085606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015540
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