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Iontophoresis of Endothelin Receptor Antagonists in Rats and Men
INTRODUCTION: The treatment of scleroderma-related digital ulcers is challenging. The oral endothelin receptor antagonist (ERA) bosentan has been approved but it may induce liver toxicity. The objective of this study was to test whether ERAs bosentan and sitaxentan could be locally delivered using i...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396598/ https://ncbi.nlm.nih.gov/pubmed/22808263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040792 |
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