Iontophoresis of Endothelin Receptor Antagonists in Rats and Men

INTRODUCTION: The treatment of scleroderma-related digital ulcers is challenging. The oral endothelin receptor antagonist (ERA) bosentan has been approved but it may induce liver toxicity. The objective of this study was to test whether ERAs bosentan and sitaxentan could be locally delivered using i...

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Main Authors: Roustit, Matthieu, Blaise, Sophie, Arnaud, Claire, Hellmann, Marcin, Millet, Claire, Godin-Ribuot, Diane, Dufournet, Boris, Boutonnat, Jean, Ribuot, Christophe, Cracowski, Jean-Luc
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396598/
https://ncbi.nlm.nih.gov/pubmed/22808263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040792
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