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Sildenafil increases digital skin blood flow during all phases of local cooling in primary Raynaud's phenomenon
Digital skin vasoconstriction on local cooling is exaggerated in primary Raynaud’s phenomenon (RP) compared to controls. A significant part of such vasoconstriction relies on the nitric oxide (NO) pathway inhibition. We tested the effect of PDE5 inhibitor sildenafil, which potentiates the effect of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000564/ https://ncbi.nlm.nih.gov/pubmed/22453196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.302 |
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