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Barium ions selectively activate BK channels via the Ca(2+)-bowl site
Activation of Ca(2+)-dependent BK channels is increased via binding of micromolar Ca(2+) to two distinct high-affinity sites per BK α-subunit. One site, termed the Ca(2+) bowl, is embedded within the second RCK domain (RCK2; regulator of conductance for potassium) of each α-subunit, while oxygen-con...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396499/ https://ncbi.nlm.nih.gov/pubmed/22733762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204444109 |
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